Table 1 Nominal parameters for the stochastic model

From: Stochastic modelling reveals mechanisms of metabolic heterogeneity

 

Value

Unit

n s

3000

molecule

k 1

1

s−1 molecule−1

k −1

1000

s−1

k cat

3.6

s−1

k rev

0.01

s−1 molecule−1

k c

0.02

s−1

k tx

0.0270

s−1

k tl

0.2

s−1

k on

0.0225

s−1

k off

0.0075

s−1

k deg

0.2

s−1

ÎŽ

0.00025

s−1

  1. Parameters correspond to the simulations of Fig. 1a. We use realistic enzyme kinetic parameters49 and fast promoter switching according to measured ranges56. The dilution rate constant ή corresponds to a doubling rate of approximately 46 min, typical in the Escherichia coli bacterium. The distributions in Fig. 1c were obtained with perturbed promoter switching parameters kon = 0.01 s−1 and koff = {0.03, 0.01, 0.0001} s−1. The parameter values for Figs. 2 and 3 are shown in the respective captions
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