Fig. 3

Binding sites for transcription factors with predicted pioneer function co-occur with LHX2 peaks. a, b Hierarchical clustering of LHX2 ChIP-Seq regulatory motifs and assigned representative logos are represented at E14 (a) and P2 (b) (linkage = average; similarity threshold cor = 0.6, ncor = 0.4, w = 5). The most enriched cluster comprises LHX2 and multiple variations of the same motif. c, d Known transcription factor motifs preferentially enriched in either E14 or P2 LHX2 ChIP-Seq peaks and identified by pairwise comparison are shown. Percentage of motif occurrences are reported for input and background datasets. The relative expression level of the corresponding transcription factor mRNA at E14/P2 is indicated by the blue/red color gradient, respectively