Fig. 2

IFNA2, IFNB1, and IFNW1 signatures separate SLE tissues from controls. GSVA enrichment scores using the PBMC IFNA2, IFNB1, IFNW1, IFNG, IL12, or TNF-induced transcripts and a random signature (Random Gr1) (Supplementary Data 2, Supplementary Fig. 3) were calculated for (a) discoid lupus erythematosus (DLE) and healthy control skin, (b) SLE synovium and osteoarthritis (OA) synovium, (c) lupus nephritis (LN) glomerulus (Glom) class III/IV and control kidney Glom and (d) LN tubulointerstitium (TI) class III/IV and control kidney TI. Hedge’s G effect size (Effect) measures are shown for cytokine signatures significantly enriched in SLE affected tissues compared to control tissues as determined by a p value < .05 using the Welch’s t-test. N.S. signifies a Welch’s t-test value ≥ .05. For LN tissues, recalculation of effect size values without the five IFN negative tissues roughly doubled the effect size values for the type I IFNs: IFNW1 (Glom g = 5.5, TI g = 3.3), IL12 (Glom g = 4.9, TI g = 1.9); IFNG (Glom g = 5.5, TI g = 2.2), IFNB1 (Glom g = 6.0, TI g = 3.0), IFNA2 (Glom g = 6.6, TI g = 3.1), but they were still lower than the effect size values calculated for the DLE and SLE synovium