Fig. 6

SLE patients may lose or gain the IGS over time. An Ftest differential expression analysis of SLE patients on standard of care treatment at zero, 16 and 52 weeks from SLE time course datasets GSE88885 and GSE88886 was carried out and GSVA enrichment scores were calculated using the IFN core signature. The straight dashed line represents the average IFN core GSVA score plus two standard deviations for the healthy controls and the lines represent SLE patients. Changes in the IGS score of greater than 0.2 SD were considered significant (Supplementary Data 9, 10). For the GSE88885 SLE dataset (a) 54 SLE patients had minimal changes in their IGS, (b) 18 SLE patients changed from negative to positive score, and (c) 14 SLE patients changed from positive to negative enrichment score. For the GSE88886 SLE dataset, (d) 23 SLE patients had minimal changes in their IFN core GSVA enrichment score, (e) five SLE patients changed from negative to positive, and (f) five changed from positive to negative IGS enrichment score