Fig. 3 | Communications Biology

Fig. 3

From: Structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase reveals mechanism of substrate binding and metal catalysis

Fig. 3

Comparison of CDP-DAG and metal ion coordination in the two protein chains of the homodimer. Chain A (“tight”) and Chain B (“relaxed”) metal coordination positions corresponding to Mg2 being located in the a and b binding sites respectively (see also Fig. 1e). CDP-DAG is shown in cyan. Relevant hydrogen bonds are shown as dashed lines and their distances are expressed in Å. Solvent molecules are shown as smaller red spheres, Mg ions—as green spheres. The signature motif of the CDP-alcohol phosphotransferases in the bottom panel is shown with M. tuberculosis PgsA1 residue numbering

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