Fig. 6 | Communications Biology

Fig. 6

From: High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes

Fig. 6

Model of receptor engagement of SfEiger. a Model of the interaction between SfEiger and a receptor. The SfEiger surface is coloured in white, while the receptor is coloured in purple and shown in cartoon representation. The single CRD was aligned onto SfEiger using PDBID 4V46. b Closeup of the putative region of interaction with the receptor. SfEiger is coloured white, the receptor in purple and conserved residues at the interaction interface are coloured in teal and shown as sticks. c View of a trigonal sheet of Eiger trimers (shown in green) related by crystallographic packing. The modelled receptor (purple) is included to show the absence of steric clashes. A hypothetical, sparser hexagonal lattice is indicated (see Discussion). d Model of laterally interacting SfEiger trimers, bound to receptors at the cell surface. The recruitment of dTRAF2 and downstream activation of JNK signalling is shown schematically

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