Table 2 Associations of genetically predicted insulin, insulin adjusted for BMI and insulin resistance genetic score with myocardial infarction, angina, and heart failure

From: Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank

Outcomes

Data source

Sex

No. of cases

Insulin

Insulin adjusted for BMI

Insulin resistance genetic score

OR

95% CI

p

OR

95% CI

p

OR

95% CI

p

Myocardial infarction

UK Biobank

Overall

14,442

2.87

1.30 to 6.33

0.009

2.63

1.36 to 5.07

0.004

3.23

1.88 to 5.56

2.4 × 10−5

Men

11,182

4.27

1.60 to 11.3

0.004

3.60

1.46 to 8.83

0.005

4.17

2.24 to 7.77

6.9 × 10−6

Women

3260

0.80

0.23 to 2.84

0.73

0.96

0.30 to 3.09

0.95

1.41

0.46 to 4.29

0.55

CARDIoGRAMplusC4D 1000 Genomes

Overall

42,561

1.90

1.04 to 3.49

0.04

2.20

1.08 to 4.50

0.03

--

--

--

Meta-analysis

Overall

57,003

2.21

1.37 to 3.58

0.001

2.42

1.49 to 3.93

0.0003

--

--

--

Angina

UK Biobank

Overall

21,939

2.05

0.87 to 4.83

0.10

1.90

0.92 to 3.94

0.08

2.87

1.84 to 4.48

3.7 × 10−6

Men

14,331

2.93

1.27 to 6.73

0.01

2.74

1.21 to 6.19

0.02

3.56

2.04 to 6.22

8.3 × 10−6

Women

7608

1.10

0.38 to 3.18

0.87

1.00

0.46 to 2.19

1.00

1.96

0.93 to 4.12

0.08

Heart failure

UK Biobank

Overall

5537

0.98

0.37 to 2.61

0.97

1.18

0.45 to 3.14

0.74

1.00

0.42 to 2.35

1.00

Men

3935

1.17

0.30 to 4.64

0.82

1.90

0.62 to 5.82

0.26

1.71

0.62 to 4.74

0.30

Women

1602

0.64

0.06 to 7.18

0.72

0.37

0.03 to 4.05

0.41

0.28

0.06 to 1.34

0.11

  1. BMI body mass index, CI confidence interval, OR odds ratio
  2. Inverse variance weighting with random effects was used for insulin and insulin adjusted for BMI; logistic regression was used for insulin resistance genetic score
  3. The bold values denote associations with confidence intervals not including the null
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