Table 1 Short-term treatment with the REV-ERB agonist SR9009 post-mI/R benefits long-term cardiac structure and function

From: SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome

 

mI/R+SR9009

mI/R+vehicle

Sham

n

10

10

6

Echocardiography baseline

 LVIDd (mm)

4.02 ± 0.02

4.01 ± 0.02

4.02 ± 0.03

 LVIDs (mm)

2.41 ± 0.03

2.43 ± 0.04

2.39 ± 0.03

 EF (%)

76.81 ± 0.60

76.21 ± 0.87

77.76 ± 0.53

 FS (%)

39.91 ± 0.53

39.75 ± 0.64

40.69 ± 0.50

 HR (bpm)

472 ± 5

472 ± 4

468 ± 7

1 week post-mI/R

 LVIDd (mm)

4.14 ± 0.04*

4.49 ± 0.11

4.01 ± 0.03

 LVIDs (mm)

2.65 ± 0.05*

3.23 ± 0.14

2.38 ± 0.02

 EF (%)

72.31 ± 0.87*

60.75 ± 2.24

77.55 ± 0.49

 FS (%)

36.15 ± 0.68*

28.22 ± 1.54

40.54 ± 0.44

 HR (bpm)

455 ± 7

460 ± 8

474 ± 7

4 weeks post-mI/R

 LVIDd (mm)

4.35 ± 0.03*

4.80 ± 0.09

4.05 ± 0.03

 LVIDs (mm)

2.90 ± 0.04*

3.65 ± 0.10

2.43 ± 0.03

 EF (%)

68.37 ± 0.82*

53.84 ± 1.44

76.78 ± 0.58

 FS (%)

33.14 ± 0.57*

23.92 ± 0.79

39.81 ± 0.53

 HR (bpm)

468 ± 4

469 ± 5

485 ± 5

8 weeks post-mI/R

 LVIDd (mm)

4.38 ± 0.04*

4.92 ± 0.11

4.05 ± 0.04

 LVIDs (mm)

2.99 ± 0.07*

3.77 ± 0.12

2.39 ± 0.03

 EF (%)

66.44 ± 1.67*

53.31 ± 1.46

78.10 ± 0.48

 FS (%)

31.93 ± 1.15*

23.61 ± 0.84

40.99 ± 0.45

 HR (bpm)

461 ± 9

449 ± 4

471 ± 3

Hemodynamics and morphometry 8 weeks post-mI/R

 LVESP (mmHg)

97.11 ± 1.29*

91.43 ± 1.03

98.09 ± 2.14

 LVEDP (mmHg)

1.66 ± 0.84

1.83 ± 0.62

0.04 ± 0.55

 LVESV (μl)

17.83 ± 1.15*

28.58 ± 1.70

10.85 ± 0.68

 LVEDV (μl)

42.02 ± 1.04*

48.90 ± 1.30

37.19 ± 0.96

 SV (μl)

24.19 ± 0.68*

20.32 ± 0.79

26.34 ± 0.64

 CO (mL min−1)

12.16 ± 0.47*

9.97 ± 0.32

13.33 ± 0.64

 +dP/dtmax (mmHg s−1)

9302 ± 339*

7275 ± 358

10093 ± 819

 −dP/dtmin (mmHg s−1)

−8543 ± 223*

−6621 ± 374

−9262 ± 517

 SBP (mmHg)

95.87 ± 0.86*

91.12 ± 0.66

97.76 ± 1.24

 DBP (mmHg)

58.67 ± 0.79

57.28 ± 1.31

61.93 ± 1.40

 MAP (mmHg)

70.34 ± 0.61

67.88 ± 0.95

72.91 ± 1.15

 HW (mg)

125.30 ± 1.77*

136.10 ± 2.03

118.00 ± 1.00

 HW:BW (mg g−1)

4.35 ± 0.09*

4.64 ± 0.06

3.96 ± 0.12

 BW (g)

28.89 ± 0.64

29.37 ± 0.48

30.02 ± 1.01

 HR (bpm)

503 ± 13

495 ± 22

506 ± 18

  1. LVIDd left ventricle internal dimensions at diastole, LVIDs LV internal dimensions at systole, % EF % ejection fraction, % FS % fractional shortening, HR heart rate, LVESP left ventricle (LV) end systolic pressure, LVEDP LV end diastolic pressure, LVESV LV end systolic volume, LVEDV LV end diastolic volume, SV stroke volume, CO cardiac output, dP/dtmax and dP/dtmin maximum and minimum first derivative of LV pressure, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, HW heart weight, BW body weight
  2. n  =  8 mI/R+SR9009, mI/R+vehicle, n  =  6 sham for hemodynamics. *p < 0.05 mI/R+SR9009 vs. mI/R+vehicle, by Student’s t test. Values are mean  ±  SEM
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