Fig. 7
From: Mechanical strain promotes skin fibrosis through LRG-1 induction mediated by ELK1 and ERK signalling
FAK or ERK inhibitor injection blocks mechanical loading-induced LRG-1 expression and attenuate scar formation. a, b Immunohistochemistry staining for LRG-1 and CD31 in mouse scar tissues of the loading group, loading with FAK inhibitor (PF573228) injection group, and loading with ERK inhibitor (PD98059) injection group and expression level quantification. (Scale bar = 50 μm). c Images of scars and gross area quantification at all examined time points. The dashed lines outline the scar. (Scale bar = 3 mm). d Images of H&E stained sections and cross-section size quantification. The dashed lines outline the scar. (Scale bar = 500 μm). Data are presented as mean ± SD. n = 15 biologically independent animals. *P < 0.05, **P < 0.01, ***P < 0.001
