Table 1 Summary of clusters and expressed genes

From: Single-cell RNA-sequencing analysis of estrogen- and endocrine-disrupting chemical-induced reorganization of mouse mammary gland

ID

Vehiclea

E2a

E2 + PBDEa

Key genes

Cell type

C0

33.4

9.8

10.1

Col1a1, Col1a2, Col6a1, Mmp2, Tnxb

ECM/fibroblast

C1

27.8

11.2

9.9

Col1a1, Col1a2, Col6a1, Mmp2, Tnxb

ECM/fibroblast

C2

3.5

28.7

10.8

Col1a1, Col1a2, Col6a1, Mmp2, Tnxb

ECM/fibroblast

C3

14.6

12.5

13.9

Col1a1, Col1a2, Col6a1, Mmp2, Tnxb

ECM/fibroblast

C4

0.6

13.3

22.7

Krt18, Krt19, Epcam, Cited1, Areg

Mature luminal cells

C5

1.2

14.1

20.6

Krt18, Krt19, Epcam, Csn3, Kit

Luminal progenitor/mature luminal cells

C6

12.7

0.8

0.9

Ptprc

Immune cells

C7

2.0

3.9

5.1

Acta2, Krt14, Krt5, Mylk, Myl9, Tagln

Basal cells

C8

1.6

2.2

1.9

Ptprc

Immune cells

C9

1.5

1.5

2.4

Ptprc

Immune cells

C10

1.1

2.0

1.7

Id1, Pecam1, Egfl7, Apold1, Plvap, Lrg1, Fabp4

Endothelial cells

  1. aValues are presented as percentages of total number of cells per treatment group (e.g., 33.4% of cells from vehicle-treated group are clustered in C0)
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