Fig. 4
From: RGS2 drives male aggression in mice via the serotonergic system
Rescue of RGS2 in serotonergic neurons recovers aggression in resident intruder test. Increased number and duration of attacks over a 10 min testing period from Rgs2-rescued mice, Rgs2−/−/ePet-Rgs2lo (b) and Rgs2−/−/ePet-Rgs2hi (c) compared to Rgs2−/− mice (a) on resident intruder day 10. The number of mice tested/group is indicated within parentheses. The average duration of attacks (d), latency to first attack (e), and number of bites (f) from Rgs2−/− mice (diamonds) compared to control (circles), Rgs2-rescued, Rgs2−/−/ePet-Rgs2lo (triangles), and Rgs2−/−/ePet-Rgs2hi (squares) mice are depicted as bar graphs. Rgs2-rescued mice showed augmented number and duration of attacks and reduced latency to first attack compared to their Rgs2−/− littermates. As expected, control mice demonstrated increased duration of attacks and reduced latency to first attack compared to their Rgs2−/− littermates. The number of mice tested/group is indicated within parentheses. Data are reported as mean ± SEM. Statistical significance was evaluated with ANOVA (*p < 0.05, **p < 0.01)
