Fig. 5
Systemic administration of histamine induces vascular leak in SJL and B10.S-HisthSJL but not B10.S mice. a, b EB was injected i.v. followed by i.p. injection of histamine (12.5 mg/kg) in either young (8-week old) mice primed with CFA (a) or aged mice (>6 months of age) (b). Extravasated dye was normalized to dry weight of the tissue/organ and expressed as fold change compared with controls (PBS). Each symbol represents an individual mouse; two independent experiments were performed; *p < 0.03, **p = 0.001; ***p = 0.0004, Holm-Sidak corrected t test
