Table 1 SJL mice exhibit age and/or inflammation-dependent histamine hypersensitivity (Histh)

From: A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease)

A

B

Strain

Histamine (mg/kg)

aged

8 week

Strain

Histamine (mg/kg)

CFA aged

8 week

SJL/J

100

4/4

0/4

SJL/J

100

4/4

4/4

50

4/4

0/4

50

4/4

4/4

25

2/4

0/4

25

4/4

4/4

12.5

0/4

0/4

12.5

0/4

0/4

SJL/NCr

100

4/4

0/4

SJL/NCr

100

4/4

4/4

50

4/4

0/4

50

4/4

4/4

25

2/4

0/4

25

4/4

4/4

12.5

0/4

0/4

12.5

0/4

0/4

B10.S/SgMcdJ

100

0/4

0/4

B10.S/SgMcdJ

100

0/4

0/4

50

0/4

0/4

50

0/4

0/4

25

0/4

0/4

25

0/4

0/4

12.5

0/4

0/4

12.5

0/4

0/4

(B10.S x SJL) F1

100

0/4

0/4

(B10.S x SJL) F1

100

0/4

0/4

50

0/4

0/4

50

0/4

0/4

25

0/4

0/4

25

0/4

0/4

12.5

0/4

0/4

12.5

0/4

0/4

  1. Young (8–10-week old) or aged (>6 months) mice were left untreated or pretreated with CFA by intraperitoneal (i.p.) injection and challenged 30 days later with the indicated doses of histamine (mg/kg) by i.v. injection. Deaths were recorded at t = 30 min. Results are expressed as the number of deaths/total mice
  2. CFA complete Freund’s adjuvant
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