Fig. 1: Base-editing by BE4 and ABE in mouse embryos.
From: Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
a Experimental design of the family based trio study. b Alignment of sequences from founder mice. 33 mutant alleles edited by ABE, and 17 alleles edited by BE4 were analyzed. The sgRNA sequence is underlined and the PAM sites shown in green. The target nucleotides and edited nucleotide are shown in bold black and blue, respectively. Unintended nucleotide substitutions are shown in red. Deletions are marked with a deletion symbol.
