Table 1 Summary of data obtained from mouse zygotes co-injected with ABE or BE4 mRNA and a sgRNA.
From: Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
No. of Parents | Base editor | No. of injected embryos | No. of embryos implanted | No. of pups born | No. of pups with mutation |
|---|---|---|---|---|---|
1 male | Control | – | 68 | 13 | – |
8 female | ABE | 196 | 124 | 13 | 13 |
(~500 pooled zygotes) | BE4 | 170 | 120 | 9 | 9 |
