Fig. 2: The concentration-dependent motility inhibitory effect of DEC on adult female B. malayi in 24-well plates and their motility recorded with the Worminator system.
From: Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi
a Control, 10 and 30 µM DEC effects on adult B. malayi at 30 s. In the control, the worms move normally (gray arrow): in 10 µM they are somewhat curled (pale blue arrow); in 30 µM (darker blue arrow) they are curled into a ball (scale bar = 0.5 cm). b Normalized motility plots over time from the Worminator following addition of different concentrations of DEC. Note the concentration-dependent differences and the recovery over time (n = 12 worms per concentration, from four deliveries of FR3 worms; total worms 60 adult females). c The DEC concentration-dependent effect on the inhibition of motility at 30 s from the worms shown in b. The IC50 was 4.4 ± 0.3 µM (n = 12 worms per concentration, 5 concentrations from 4 deliveries of FR3 worms; total worms 60 adult females).
