Fig. 9: cenBAF, PP4, and CENP-C form a centromeric network that prevents PP2A-mediated dephosphorylation and perichromosomal accumulation of BAF in mitosis. | Communications Biology

Fig. 9: cenBAF, PP4, and CENP-C form a centromeric network that prevents PP2A-mediated dephosphorylation and perichromosomal accumulation of BAF in mitosis.

From: A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression

Fig. 9

a Normally, centromeric localization of cenBAF and PP4, which depends on CENP-C, maintains PP2A inactive (in red) during mitosis and, consequently, the bulk of BAF stays phosphorylated and free. b Disrupting centromeric localization of cenBAF and PP4 causes ectopic PP2A activation (in green) in mitosis, which results in dephosphorylation of pBAF and the accumulation of perichromosomal BAF. Centromeric CENP-C is also destabilized. See text for details.

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