Fig. 4: The compounds and proteins with high degrees or high occurrences in the shortest pathways.

From the networks using LCTE to relieve each symptom or ‘viral respiratory infection’, the top five compounds and proteins (if there were any) were extracted based on both the vertex degree (red dots) and the frequencies with which the vertex appears in the shortest pathways (NSP) (blue dots). To avoid overlapping the dots, we used color transparency (alpha = 0.8) and dot position jitter (width = 0.2, height = 0). The dot sizes are based on the degree or the frequency at which the vertex appears in the shortest pathways. HADHB stands for hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta, while the full names and abbreviations of other proteins are given in the plot.