Fig. 3: Dynamics of intracellular ATP in cortical neurons and CBF during sub-state changes.
From: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states
a Trace of averaged ATP and CBF signals, and EEG power (n = 4 mice) through the transition from quiet-awake to active-awake states. Transitions occurred at 0 s. Black bar = statistical period. Colored bar = p < 0.05; paired t-test with Bonferroni correction (during 4 s just before the onset of active-awake vs. that during each 1 s period for 8 s after the onset of active-awake, n = 4 mice). (b) Peak time of ATP signal and peak and trough time of CBF signal after the onset of active-awake. *p < 0.05; Student’s t-test with Bonferroni correction (n = 4 mice), mean ± SEM. c Trace of averaged ATP and CBF signals and EEG power (n = 4 mice) at micro-awakening during the non-REM sleep state. Micro-awakening occurred at 0 s. d Peak time of ATP signal and peak and trough time of CBF signal after the onset of micro-awakening. *p < 0.05, **p < 0.01; Student’s t-test with Bonferroni correction (n = 4 mice), mean ± SEM.
