Table 2 The decomposed relaxation reservoirs of packed red blood cells with the hemoglobin variants in (a) wild-type (control), (b) HbE variant, (c) HbD variant, and (d) rare beta thalassemia variant.

From: Machine learning assistive rapid, label-free molecular phenotyping of blood with two-dimensional NMR correlational spectroscopy

Bulk water, R-peak

T1 (ms)

T2 (ms)

A ratio

a. Hb wild-type (control)

562

141

3.99

b. HbE variant

631

158

3.99

c. HbD variant

640

165

3.88

d. rare Hb variant

640

165

3.88

Hydration layer, S-peak

T1 (ms)

T2 (ms)

A-ratio

a. Hb wild-type (control)

335

4.47

74.94

b. HbE variant

335

4.22

79.39

c. HbD variant

373

4.18

89.23

d. rare Hb variant

362

6.48

55.86

Direct bound macromolecules, T-peak

T1 (ms)

T2 (ms)

A-ratio

a. Hb wild-type (control)

188

1.12

167.9

b. HbE variant

106

1.06

100

c. HbD variant

96.3

1.20

80

d. rare Hb variant

172

1.40

122.9