Fig. 8: Possible involvement of complement in phosphate-mediated renal inflammation. | Communications Biology

Fig. 8: Possible involvement of complement in phosphate-mediated renal inflammation.

From: Urinary phosphate-containing nanoparticle contributes to inflammation and kidney injury in a salt-sensitive hypertension rat model

Fig. 8

a Renal levels of C1qa (upper panel) and tubulin (lower panel) were compared by western blotting between the DSH and DSH+2.5%SF groups. Dot plots show the results of quantitation. b Immunofluorescence study for C1qa in the indicated animals. Bars represent 20 μm. c A proposed model linking disturbed phosphate metabolism and tissue inflammation. Increased phosphate loading to renal tubules induces chemokine production including Ccl2 in renal tubules likely through the formation of CaPi nanoparticles, thereby facilitating macrophage migration. Infiltrated macrophages not only contribute to the clearance of CaPi nanoparticle through complement-mediated opsonization but also cause renal inflammation. Data are expressed as mean ± SEM; n = 5 animals per group.

Back to article page