Fig. 4: Human ex vivo electrophysiology study setup. | Communications Biology

Fig. 4: Human ex vivo electrophysiology study setup.

From: Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

Fig. 4: Human ex vivo electrophysiology study setup.

a An example of the human splenic tissue as received. The purple dots on the sample indicates the top part of the splenic artery with aorta towards the left end, and spleen on the right end of the sample (for orientation). b Placement of peri-arterial cuff around the neurovascular bundle (I), placement of a smaller diameter cuff around few nerves (III). This nerve is dissected, placed in a bath with Kreb’s solution, and traced all along till the end of the sample, where the hooks are placed to record compound action potentials c (III), d Conceptual sketch of tissue with the cuff, and hook placement, and e an example of eCAP observed on the oscilloscope.

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