Fig. 1: Paratope states of the anti-polyhydroxybutyrate antibody Fv including the results of the Markov-state model and shows the relative VH–VL interface distributions for the respective macrostates.
From: Antibodies exhibit multiple paratope states influencing VH–VL domain orientations
a Combined free energy landscape of all CDR loops with the respective four macrostate representatives. b Markov-state model, transition kinetics, and state probabilities of different paratope states for the anti-polyhydroxybutyrate antibody. c Relative VH–VL interface dynamics of the macrostate ensembles, color-coded according to the Markov-state model in (b). The horizontal line depicts the interface orientation of the crystal structure.
