Table 2 Results of computational protein–protein interaction experiments predicting the impact of single residue replacements, relative to human ACE2 residues, at critical binding sites with SARS-CoV-2 receptor-binding domain.

From: Comparative ACE2 variation and primate COVID-19 risk

Mutation

ΔΔG (kcal/mol)a

Y41H

1.929

Q42E

0.954

M82T

0.938

D38E

0.651

Q24L

−0.753

H34L

−0.566

H34Y

−0.139

D30E

0.692

  1. aMutations were analyzed with the SSIPe server (https://zhanglab.ccmb.med.umich.edu/SSIPe/) and PDB file 6M0J.
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