Table 3 Results of codeml analyses of adaptive evolution across ACE2 gene sequences.

Model	Foreground branch	ω	Proportion of sites	LRT	p	Positively selected sites^a,b
Clade C	N/A	ω₀ = 0.059, ω₁ = 1.000, ω₂ = 0.081, ω₃ = 1.123, ω₄ = 0.236, ω₅ = 1.346	p₀ = 0.581, p₁ = 0.331, p_2-5 = 0.089	26.726	<0.001	N/A
Branch-site	Platyrrhines	Background: ω₀ = 0.076, ω₁ = 1.000, ω_2a = 0.076, ω_2b = 1.000 Foreground: ω₀ = 0.076, ω₁ = 1.000, ω_2a = 6.218, ω_2b = 6.218	p₀ = 0.638, p₁ = 0.359, p_2a = 0.002, p_2b = 0.001	0.633	0.427	None
	Catarrhines	Background: ω₀ = 0.075, ω₁ = 1.000, ω_2a = 0.075, ω_2b = 1.000 Foreground: ω₀ = 0.075, ω₁ = 1.000, ω_2a = 8.988, ω_2b = 8.988	p₀ = 0.631, p₁ = 0.356, p_2a = 0.009, p_2b = 0.005	14.546	0.0001	249M (0.962), 653A (0.958), 658V (0.957*)
	Strepsirrhines	Background: ω₀ = 0.072, ω₁ = 1.000, ω_2a = 0.072, ω_2b = 1.000 Foreground: ω₀ = 0.072, ω₁ = 1.000, ω_2a = 1.384, ω_2b = 1.384	p₀ = 0.607, p₁ = 0.316, p_2a = 0.051, p_2b = 0.027	0.833	0.361	None
	Bats	Background: ω₀ = 0.075, ω₁ = 1.000, ω_2a = 0.075, ω_2b = 1.000 Foreground: ω₀ = 0.075, ω₁ = 1.000, ω_2a = 10.535, ω_2b = 10.535	p₀ = 0.626, p₁ = 0.338, p_2a = 0.024, p_2b = 0.013	42.649	<0.001	24Q (0.998*), 31E (0.959), 35E (0.974), 298V (0.959), 568L (0.998*), 575G (0.965)

^aSites with posterior probability >0.95 are shown.
^bThe amino acid shown reflects the residue present at the site in the first sequence of the alignment (Alouatta palliata).
^*Sites with posterior probability 0.95-0.99 are denoted.
^**Sites >0.99 are denoted.

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