Fig. 6: Validation of potential target proteins in malaria and dengue using MRM assays.
From: Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity
a Workflow for the validation of potential target proteins in malaria and dengue using MRM. Eighty-six proteins were considered for optimization for MRM method. ROC curves for the best panels of protein biomarkers are represented, b dengue vs. malaria, c falciparum vs. vivax, and d cerebral vs. severe anemia malaria. Violin plots showing the comparison of discovery and validation phase measurements for a few selected differentially abundant plasma proteins. e Dengue vs. malaria, f falciparum vs. vivax malaria, and g cerebral vs. severe anemia malaria. All data are represented as median (*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, and ****p ≤ 0.0001) in a Student’s t-test.
