Fig. 2: Potential therapeutic strategies related to cancer-immunity, based on interactors, specifically targeting Tet2 activities in immune and cancer cells. | Communications Biology

Fig. 2: Potential therapeutic strategies related to cancer-immunity, based on interactors, specifically targeting Tet2 activities in immune and cancer cells.

From: Tet2 at the interface between cancer and immunity

Fig. 2

The Tet2 activities might be enhanced by vitamin C and hypoxia treatment through HIF-1a. The Tet2 activities might be halted by blocking a-KG accumulation, selective OGT inhibition, selective IDH2 inhibition, using anti-Fe2+ agent, or directly suppressed by microRNAs (e.g., Let-7 and miR-22), Tet2 shRNA lentivirus, and Crispr/cas9 targeting in cancer and immune cells.

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