Fig. 1: Main experimental design in the study. | Communications Biology

Fig. 1: Main experimental design in the study.

From: Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia

Fig. 1: Main experimental design in the study.

a Representation of the NuTRAP construct and its recombined products upon cre-mediated induction. b Breeding strategy to achieve astrocyte- and microglia- specific RNA and DNA. c Schematic of the cell-specific RNA and DNA isolation from the same mouse brain via the TRAP and INTACT methods. Note: currently TRAP and INTACT from the same homogenate is not possible, but parallel structures from each hemisphere of the same mouse can be used for paired analyses.

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