Fig. 7: Possible molecular mechanism of genomic instability induced by aberrant (P)RR expression. | Communications Biology

Fig. 7: Possible molecular mechanism of genomic instability induced by aberrant (P)RR expression.

From: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H

Fig. 7

Aberrant (P)RR expression enhances SMARCA5 expression through a direct molecular interaction, which results in the failure of several genomic stability pathways. In short, aberrant (P)RR expression induces genomic instability and contributes to early carcinogenesis of PDAC.

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