Table 1 RNA-seq analysis of in vivo-grown control and shRNA-mediated depletion of DDR2 NA13 tumors, treated with IgG or anti-PD-1.

From: Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy

Gene

log2 Fold Change-Ctrl PD-1 vs Ctrl IgG

P value

FDR

log2 Fold Change-shDDR2 PD-1 vs Ctrl PD-1

P value

FDR

Adam10

−0.822596659

0.020806363

0.045585636

0.406506375

0.48972383

0.69464212

Anpep

−1.59767458

1.97872E-05

4.33527E-05

2.158521221

0.000295296

0.000418858

Ccl2

1.571613003

2.14919E-07

4.70876E-07

−1.288996781

0.021993815

0.031196828

Cd37

−0.042166571

0.941459914

0.9999

1.410860957

0.058872555

0.083506977

Col1a1

−0.167174285

0.704017938

0.9999

0.80177797

0.341239809

0.484026975

Cxcl12

0.60349953

0.094849721

0.207810699

0.50336306

0.379091454

0.537717127

Cxcr4

0.650687462

0.034177217

0.074880467

−0.306546059

0.572535787

0.812105616

Dpp4

1.338848907

0.022922195

0.050221311

0.34210444

0.649167245

0.920802468

E2f1

−0.010405546

0.967081161

0.9999

0.158559888

0.790202949

0.9999

Erbb2

−0.849235451

0.009699223

0.021250482

0.31783298

0.577566925

0.819241966

F3

−0.370653036

0.270870723

0.593463358

−0.159093063

0.763568714

0.9999

Faah

−0.439111486

0.557325622

0.9999

1.216752365

0.116775867

0.165639143

Fap

1.630442692

4.19435E-05

9.1896E-05

−0.893607113

0.122541449

0.173817256

Gstp1

0.439742236

0.199664558

0.437454436

−0.460375803

0.369549503

0.524182477

Il7r

−0.278499577

0.583310576

0.9999

1.313357477

0.035733225

0.050685308

Mmp14

−0.32431483

0.323697891

0.709204875

0.410117128

0.48862662

0.693085797

Mmp2

−0.613897569

0.076753939

0.168163802

0.972047317

0.079696089

0.113043836

Mmp9

0.083811224

0.812235689

0.9999

−0.21140455

0.697798397

0.989782665

Pdk1

0.114935953

0.708139487

0.9999

−0.349615903

0.531679849

0.754154066

Ptk2b

−0.796466967

0.04643294

0.101732105

0.402383049

0.487882786

0.692030716

Rps6kb1

−0.17291805

0.556540513

0.9999

−0.150150265

0.773998339

0.9999

Slc3a2

−0.262119972

0.434579646

0.952140908

0.320402368

0.589868823

0.836691427

Vegfc

0.037866013

0.965403498

0.9999

0.037600307

0.964890214

0.9999

  1. ‘Ctrl PD-1 vs Ctrl IgG’ depicts comparisons between scramble shRNA control treated with anti-PD-1 vs. IgG control. ‘shDDR2 PD-1 vs. Ctrl PD-1’ depicts DDR2- targeting shRNA vs scramble shRNA control treated with anti-PD-1.
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