Table 2 Associations between genetic ancestry and cSCC risk in GERA non-Hispanic whites and Hispanic/Latinos.
Non-Hispanic whites | Hispanic/Latinos | |||
|---|---|---|---|---|
β (SE) | P value | β (SE) | P value | |
Model 1: Ancestry (age, sex, and PCs as covariates) | ||||
PC1 | 30.12 (1.76) | 2.38 × 10−65 | 122.48 (8.95) | 1.27 × 10−42 |
PC2 | −25.23 (1.71) | 2.28 × 10−49 | 43.52 (15.97) | 6.44 × 10−3 |
Model 2: Model 1 and HIrisPlex-S skin pigmentation predictions | ||||
PC1 | 16.53 (1.84) | 2.42 × 10−19 | 67.31 (11.19) | 1.77 × 10−9 |
PC2 | −19.36 (1.73) | 5.33 × 10−29 | 28.43 (15.80) | 0.072 |
Intermediate skin | −1.32 (0.05) | 6.97 ×10−150 | −2.23 (0.31) | 1.54 × 10−12 |
Dark skin | −2.24 (0.17) | 3.47 × 10−41 | −3.22 (0.39) | 1.09 × 10−16 |
Model 3: Model 2 and genetic risk score | ||||
PC1 | 17.20 (1.84) | 1.07 × 10−20 | 56.54 (11.49) | 8.54 × 10−7 |
PC2 | −18.33 (1.75) | 4.41 × 10−26 | 28.44 (15.63) | 0.069 |
Intermediate skin | −0.68 (0.06) | 5.94 × 10−26 | −1.31 (0.37) | 4.54 × 10−4 |
Dark skin | −1.46 (0.17) | 4.44 × 10−17 | −2.14 (0.46) | 2.93 × 10−6 |
GRS | 0.09 (0.01) | 8.50 × 10−54 | 0.13 (0.03) | 1.26 × 10−5 |
Model 4: Model 3 and sun exposure | ||||
PC1 | 11.49 (1.90) | 1.52 × 10−9 | 41.30 (11.98) | 5.67 × 10−4 |
PC2 | −12.99 (1.80) | 5.37 × 10−13 | 18.67 (15.17) | 0.22 |
Intermediate skin | −0.45 (0.07) | 1.26 × 10−11 | −0.94 (0.39) | 0.016 |
Dark skin | −0.96 (0.18) | 4.84 × 10−8 | −1.62 (0.47) | 5.54 × 10−4 |
GRS | 0.07 (0.01) | 1.14 × 10−29 | 0.12 (0.03) | 6.84 × 10−5 |
Prior AK | 1.39 (0.02) | <2.23 × 10−308 | 1.64 (0.14) | 5.12 × 10−30 |
