Fig. 4: The NA activity affects cytokines production.
From: Influenza virus neuraminidase regulates host CD8+ T-cell response in mice
a INFα, b IFNγ, c IL-2, d IL-4, e IL-6, f IL-10, g IL-12, h IL-27, and i IL-17D production from the mice infected with 1 × 103 pfu of IAV at 4-day post-infection. j IL-17D inhibited the induction of IAV-specific CD8+ T cells. HI IL-17D: Heat inactivated IL-17D. k The relationship between the dose of IL-17D and the secreted IFNγ from CD8+ T cells. l IL-17D suppressed the activation of IAV-specific CD8+ T cells. m` Dose-dependent suppression of IFNγ secreted from the IAV-specific CD8+ T cells by IL-17D. n A model of IAV-specific CD8+ T-cell induction and activation. CD8+ T-cell induction was suppressed by IL-17D but activated by IL-27. The gray cell indicated IAV-infected cell. a–m Mean ± SD for three independent experiments. *P < 0.001, **P < 0.05.
