Fig. 6: Schematic illustration of the cellular metabolic changes in diabetic wounds that can be reversed by miR-210 reconstitution.
From: HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism
a In normal hypoxic wound cell, miR-210 is induced by hypoxia and regulates appropriate responses of mitochondrial oxygen consumption (OCR) and glycolysis. b In diabetic hypoxic wound cell, miR-210 induction is blunted, resulting in increased OCR, reduced glycolysis, and consequently elevated ROS levels which are detrimental to wound healing. c In miR-210-reconstituted diabetic hypoxic wound cells, miR-210 can reverse the metabolic changes by inhibiting OCR and enhancing glycolysis and consequently normalize ROS levels which are beneficial for wound healing.
