Fig. 9: Radixin is required for maintaining the mechanical stability of stereocilia, the function of mechanically sensitive ion channels, and hearing sensitivity.

Schematic diagram of outer hair cell stereocilia with radixin-binding area showing the molecular interactions between radixin and F-actin cytoskeleton, the transmembrane protein CD 44, and the blocker mode of action. In the hearing organ of animals where the radixin blocker DX-52-1 was not applied, the animals had normal hearing and stereocilia functions. Application of the blocker results in a disruption of the link between radixin and F-actin cytoskeleton. The animal had reduced hearing sensitivity, and large effects on OHC stereocilia functions were evident.