Fig. 5: Physiological parameters of diabetic and nondiabetic mice. | Communications Biology

Fig. 5: Physiological parameters of diabetic and nondiabetic mice.

From: miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Fig. 5

a Diabetes was induced in WT and miR-379KO mice by STZ injections as described in the “Methods.” Non-fasting blood glucose levels (BGL) in WT and miR-379KO mice at indicated time periods during 24 weeks after diabetes onset compared to control (Con) (n = 5/group). b–d, Body weights and body composition analysis using Echo/MRI system. b Body weight (n = 8/group, n = 6–9/group, and n = 5–6/group for 1, 6, and 24 weeks post diabetes onset, respectively). c Total body fat (n = 8 and n = 4 for 1 and 6 weeks of diabetes, respectively). d Total lean mass (n = 4 for 6 weeks of diabetes). e, f Kidney function (urine albumin excretion) was examined using ELISA in 24 h urine collections after 24 weeks of diabetes. e Urine albumin level (n = 4–5/group). f Albumin/creatinine ratio (ACR) (n = 4–5/group). Each dot indicates the value from each mouse. One-way ANOVA with post hoc Tukey’s test for multiple comparisons. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. All data are presented as mean ± SEM.

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