Fig. 8: Immunohistochemical staining and quantitative analysis of miR-379 target proteins. | Communications Biology

Fig. 8: Immunohistochemical staining and quantitative analysis of miR-379 target proteins.

From: miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1

Fig. 8

a, b EDEM3 (n = 32 and 50 glomeruli/group for 6 and 24 weeks, respectively), c, d FIS1 (n = 50 glomeruli/group), e, f TXN1 (n = 30 and 50 glomeruli/group for 6 and 24 weeks, respectively), and g, h PGC-1a (n = 50 glomeruli/group) protein in kidney cortex sections from WT and miR-379KO mice at 6 and 24 weeks after diabetes onset. Scale bar, 50 µm. Bar graph results are expressed as fold over WT-Con. Statistical analyses were performed by one-way ANOVA with post hoc Tukey’s test for multiple comparisons. *P < 0.05, **P < 0.01, ****P < 0.0001. All data are presented as mean ± SEM.

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