Fig. 3: Biochemical and inflammatory responses monitoring after LASV challenge. | Communications Biology

Fig. 3: Biochemical and inflammatory responses monitoring after LASV challenge.

From: Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques

Fig. 3: Biochemical and inflammatory responses monitoring after LASV challenge.

a Analysis of biological parameters during LASV infection. The data from longitudinally followed and sequentially killed animals at 2, 5, and 11 DPI were collected: controls (n = 3 animals), LASV-AV (n = 10), LASV-Josiah (n = 12). The individual data at the time before the death of all longitudinally followed LASV-Josiah-infected primates were collected to calculate the mean determined at 12 DPI. Results show the mean (curve) and individual data points for each group. Statistical analyses were performed and are presented as in Fig. 1. Quantification of pro-inflammatory cytokines b, anti-inflammatory cytokines c, chemokines d, and T-cell response-related mediators e in plasma according to the time after LASV infection. b–e Results show the mean (curve) and individual data points for each group: controls (n = 3), LASV-AV (n = 4), LASV-Josiah (n = 6). Statistical analyses were performed and are presented as in Fig. 1.

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