Fig. 8: Analysis of transcriptomic data of PBMCs.

a Heatmap of the 100 most differentially expressed (DE) genes (absolute Log2 fold-change larger than 5). Gene expression was standardized using VST transformation, hence centered and scaled to make the gene expression comparable. Each column corresponds to the mean gene expression of the three animals of each group for a given timepoint. b Heatmap of gene expression of six gene sets. Significant genes are highlighted with bold labels and corresponding significant comparisons are displayed by gray (significant difference between Josiah and AV for a given day) and black vertical bars (significant difference with the mock condition). Gene expression was standardized using VST transformation, centered and scaled to make the gene expression comparable, hence averaged by condition and timepoint. An enrichment test was performed, using a one-tailed Fisher test. P values were adjusted on multiple comparisons using Benjamini–Hochberg correction and were presented under the gene set name.