Fig. 9: Analysis of transcriptomic data of organs and of genes related to sepsis in PBMCs. | Communications Biology

Fig. 9: Analysis of transcriptomic data of organs and of genes related to sepsis in PBMCs.

From: Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques

Fig. 9

Heatmap of gene expression of five gene sets in spleen a MLN, b, and liver c presented as in Fig. 8b, except that only the DE genes are listed. Gene expression was standardized using VST transformation, hence centered and scaled to make the gene expression comparable. Each column corresponds to the mean gene expression of the three animals of each group for a given timepoint. The Log2 fold-changes of genes found DE in this study and known to be upregulated d or downregulated e in PBMCs during severe sepsis were calculated between PBMCs of LASV-infected and mock animals and represented by light and dark colors for 4 and 10 DPI, respectively.

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