Fig. 7: BB diet and HA promote bone development in wild type mice but not in GPR109A−/− mice. | Communications Biology

Fig. 7: BB diet and HA promote bone development in wild type mice but not in GPR109A−/− mice.

From: GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

Fig. 7

Four-week-old male wild type and GPR109A−/− mice were fed with %5 BB diet and three different doses of HA supplemental diets for 6 weeks. a Representative micro-CT images (sagittal view above, axial view below) of the proximal tibial from one sample from each group of wild type mice, white color lines and dots show bone. b Micro-CT measured parameters from with or without BB or HA treatments of wild type mouse groups. BV/TV, bone volume / total tissue volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular separation. c Representative micro-CT images (sagittal view above, axial view below) of the proximal tibial from one sample from each group of GPR109A−/− mice, white color shows bone. d Micro-CT measured parameters from with or without BB or HA treatments of GPR109A−/− mouse groups. Data are expressed as mean ± SD (n = 6 per group); *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 as determined by one-way ANOVA followed by Student-Newman-Keuls posthoc analysis for multiple pairwise comparisons to control.

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