Fig. 5: Hypothesized model of antiviral apoptosis in the Aedes aegypti midgut. | Communications Biology

Fig. 5: Hypothesized model of antiviral apoptosis in the Aedes aegypti midgut.

From: Clustered rapid induction of apoptosis limits ZIKV and DENV-2 proliferation in the midguts of Aedes aegypti

Fig. 5

a RIA of infected cells in the midgut epithelium within 2 hours of an infected blood meal arrests viral replication before progeny virions can be produced and suppresses infection. The clustered appearance of apoptotic cells may be caused by pro-apoptotic signaling to neighboring cells. b At later timepoints post infection, when infection is widespread throughout the midgut and progeny virions are being produced, death of infected cells may facilitate release of virions from cells and/or from the midgut by degrading the integrity of the epithelium and basal lamina.

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