Fig. 1: SDHB c.C136U RNA editing is induced in M1 macrophages and mediated by A3A.
From: RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
a RNA editing was induced in M1 macrophages but not in M0 or M2 macrophages (n = 2 replicates from 1 representative donor). b A3A was required for SDHB RNA editing. P = 0.0001, Paired t test, two-tailed, n = 8 donors. c IFN-1 (IFN-α, 1000 U/ml) induces RNA editing in ovarian tumor associated macrophages (TAMs) from ascites of ovarian cancer patients. P = 0.0084, Paired t test, two-tailed, n = 5 donors. Data in scatter dot plots with mean ± SD. (see “Methods” section for macrophage polarization and KD protocol.).
