Fig. 5: A3A augments inflammatory gene expression in M1-polarized macrophages.
From: RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
Volcano plot of SC vs. A3A KD macrophages highlight selected inflammatory genes. Positive log2FC values represent enriched expression in SC and negative values enriched in KD. Plot highlights that A3A expression is significantly enriched in SC relative to KD, indicating effective knockdown and that A3A is required for high expression levels of pro-inflammatory genes IL6, IL23A, IL12B and CD86 in M1 macrophages. Vertical lines indicate absolute 2-fold-change values and the horizontal line FDR = 0.05.
