Table 1 Demographics and clinical assessments.

From: Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease

Characteristic

Controls

n = 30

PD high visual performers

n = 58

PD low visual performers

n = 30

Statistic

Age (years)

66.8 (9.3)

66.8 (9.3)

64.4 (8.0)

0.001b

Male (%)

13 (43.3)

13 (43.3)

48 (54.5)

0.334

Years of education

17.7 (2.5)

17.7 (2.5)

17.1 (2.9)

0.098

Vision

 Contrast sensitivity (Pelli–Robson)a

1.8 (0.2)

1.8 (0.2)

1.7 (0.1)

<0.001b

 Acuity (LogMar)a

−0.08 (0.2)

−0.08 (0.2)

−0.08 (0.1)

0.441

 Colour vision (D15)

1.3 (1.3)

1.1 (0.8)

1.6 (1.8)

0.334

General cognition

 MOCA

28.8 (1.3)

28.8 (1.3)

27.9 (2.4)

0.003b

 MMSE

29 (1.1)

29 (1.1)

28.9 (1.3)

0.573

Mood

 HADS anxiety

3.7 (3.4)

3.7 (3.4)

5.9 (3.1)

0.023b,c

 HADS depression

1.9 (1.4)

1.9 (1.4)

4.1 (3.1)

<0.001b,c

Disease-specific measures

 Years from diagnosis

3.7 (2.6)

4.5 (2.6)

0.061

 UPDRS total score

44.2 (25.5)

49.9 (26.8)

0.315

 UPDRS motor score

23. 2 (14.1)

24.3 (14.8)

0.785

 LEDD

411.1 (273.5)

479.4 (201.2)

0.099

 RBDSQ

4.4 (2.7)

4.0 (2.1)

0.832

Image quality metrics

 Coefficient of joint variationd

0.69 (0.3)

0.69 (0.3)

0.67 (0.2)

0.925

 Entropy focus criteriond

0.59 (0.1)

0.59 (0.1)

0.59 (0.1)

0.167

 Total Signal to noise ratioe

1.89 (0.2)

1.89 (0.2)

1.85 (0.2)

0.314

 Mean framewise displacemente

0.17 (0.1)

0.17 (0.1)

0.19 (0.1)

0.056

  1. All data shown are mean (SD) except gender.
  2. In bold characteristics that significantly differed between groups.
  3. HADS Hospital anxiety and depression scale, MMSE Mini-mental state examination, MOCA Montreal cognitive assessment, UPDRS Unified Parkinson’s Disease Rating Scale, LEDD Levodopa Equivalent Dose, RBDSQ REM sleep behaviour disorder scale.
  4. aBest binocular score used; LogMAR: lower score implies better performance, Pelli–Robson: higher score implies better performance.
  5. bStatistically significant difference between PD and controls.
  6. cStatistically significant difference between PD high visual performers and PD low visual performers.
  7. dHigher values imply worse image quality.
  8. eHigher values imply better image quality.