Table 3 Neurotransmitter receptor genes correlating with the change in structural–functional connectivity coupling in PD.

From: Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease

Genes correlated with structural–functional connectivity decoupling in PD compared to controls

Gene symbol

Ligand

Correlation coefficient

q value

CHRNA4

Acetylcholine

0.210

<0.001

DRD2

Dopamine

−0.165

0.006

HTR1E

Serotonin

0.140

0.027

HTR2A

Serotonin

−0.239

<0.001

HTR2C

Serotonin

−0.251

<0.001

HTR4

Serotonin

−0.234

<0.001

Genes correlated with structural–functional connectivity decoupling in PD low visual performers compared to PD high visual performers

Gene symbol

Ligand

Correlation coefficient

q value

ADRA2A

Norepinephrine

−0.133

0.041

CHRNA2

Acetylcholine

0.211

<0.001

CHRNA3

Acetylcholine

−0.194

0.001

CHRNA4

Acetylcholine

0.180

0.002

HTR1E

Serotonin

0.237

<0.001

HTR5A

Serotonin

0.308

<0.001

  1. Note that correlation coefficients of absolute values between 0.1 and 0.4 represent moderate correlation in our dataset. In all cases, gene expression levels were significant in spatial permutation testing (p-spin < 0.001).
  2. CHRNA Nicotinic Cholinergic Receptor (Alpha), DRD Dopamine Receptor D, HTR 5-Hydroxytryptamine Receptor, ADRA Alpha-1A adrenergic receptor.
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