Fig. 2: Two divergences between the five structures of the MERS-CoV macro domain in complex with different NAD metabolites. | Communications Biology

Fig. 2: Two divergences between the five structures of the MERS-CoV macro domain in complex with different NAD metabolites.

From: Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites

Fig. 2: Two divergences between the five structures of the MERS-CoV macro domain in complex with different NAD metabolites.

A Two distinguished loops in protein structures complexed with ADPR, NAD, ATP, ADP, and AMP are represented by ribbon models colored in light green, orange, yellow, cyan, and light pink, respectively. B The closed/open states of the ligand-binding pocket result from the orientation of residues, G45, G46, and I126, located on the two distinguished loops.

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