Fig. 7: A tunable ligand-binding site of the MERS-CoV macro domain.
From: Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolites
A Ligand binding site of MERS-CoV macro domain complexed with different NAD metabolites colored according to the B-factor putty script distributed with PyMOL. Distinguished loops are labeled by symbols, stars (*), and crosses (+). B Comparison of normalized B factor among various NAD metabolite-bound forms of the MERS-CoV macro domain. The flexibility difference at the distinguished loops of the ligand-binding site (*, +) is shown by insert plots of normalized B factor vs. residue number. C NMR relaxation parameters, R1, R2, NOE, of the MERS-CoV macro domain apo form, ADPR-complex, and NAD-complex form labeled by blue circles, red squares, and green triangles, respectively. The left and right panel show relaxation parameters determined at 298 K and 308 K, respectively. Parts of distinguished loops (*, +) are colored in yellow.
