Fig. 2: Correlation between proteomics and trancriptomics data for the PCa selected enriched proteins.

a Summary table showing the gene symbol & name, median gene rank and corresponding P-value obtained with Oncomine (n = 1128) for the PCa enriched proteins identified with a higher number of PSMs. The median rank for a gene is the rank for the gene across each of the analyses for the 16 data sets assessed. The P-value for a gene is the P-value for the median ranked analysis. The heatmap on the right indicates the level of expression for each gene in each study selected (blue: least expressed, red: most expressed). Each square represents each Oncomine study that met our eligibility criteria and thresholds (see “Methods” section). Colors are z-score normalized to depict relative values within a row. Proteins found in PCa samples and upregulated in prostate carcinoma vs. normal prostate gland (Oncomine) are boxed in black. N/A ^a: not applicable. b Tukey box plots showing median gene expression of SLC12A2, DDAH1, NDRG1, APOE, YWHAZ, and GDF15 comparing tumor vs. Normal adjacent tissues using the TCGA-PRAD data set (n = 499). The top and bottom of each rectangular box represent the 75th and 25th percentiles, respectively, with the median indicated with a solid line inside the box. Horizontal bars extending from each box represent more extreme values defined as 1.5-times the interquartile range (25th percentile subtracted from the 75th percentile) above the 75th percentile or below 25th percentile. Circles represent outliers. Student’s t-test was used to ascertain statistical significance. Statistical significance was set at P ≤ 0.05. c Protein levels (PSMs) and gene differential expression (PCa vs. normal adjacent tissue, TCGA-PRAD) of PCa selected enriched proteins were put together in a proteogram plot.