Fig. 3: Overall survival (OS) of PCa patients naive of treatment based on YWHAZ, NDRG1, APOE, GDF15, and SLAC12A2 expression (Sboner data set, GSE16560, n = 281).
From: The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer
a Kaplan–Meier curves for OS for PCa patients segregated based on the gene expression levels for YWHAZ, NDRG1, APOE, GDF15 and SLAC12A2. OS of patients with high (red dotted-lines) vs. low (blue full-lines) expression for each gene. b Multivariable analyses presented by forest plots including each gene with GS, age or TMPRSS2-ERG fusion or all the variables together. Statistical significant associations are bolded. Multivariable analysis w/Gleason (light blue) = adjusted for GS (6; 7 (3 + 4); 7 (4 + 3); 8–10). Multivariable analysis w/age (purple) = adjusted for age at diagnosis (age groups: 50–70; 70–80; 90–100). Multivariable analysis w/TMPRSS2-ERG fusion (green) = adjusted for TMPRSS2-ERG fusion. Multivariable analysis (red) = adjusted for GS, age at diagnosis and TMPRSS2-ERG fusion. GS = Gleason score. HR = hazard ratios [95% confidence interval] for the univariable analysis. All comparisons consider low expression patients as the reference group. P = Cox proportional hazard model P-value. Statistical significance was set at P ≤ 0.05.
