Fig. 4: YWHAZ and NDRG1 as risk stratification genes in PCa patients naive of treatment (Sboner data set, GSE16560, n = 281).
From: The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer
a Multivariable analyses based on gene expression of YWHAZ, NDRG1, APOE, GS, age and TMPRSS2-ERG fusion for patients with PCa. P = Cox proportional hazard model P-value. b Heatmap depicting low (blue) or high (red) NDRG1 and YWHAZ gene expression for patients with PCa. Patient subgroups are presented in black boxes. c–g OS of patients with low YWHAZ and NDRG1 gene expression (1), high NDRG1 gene expression (2), high YWHAZ gene expression (4), and high YWHAZ and NDRG1 gene expression (3). Kaplan–Meier curves for OS for PCa patients segregated based on gene expression levels for YWHAZ and NDRG1 (c), gene expression levels for YWHAZ and NDRG1 for GS 7 (d) and GS 8–10 (e), and gene expression levels for YWHAZ and NDRG1 for GS 7 (3 + 4) (f) and GS 7 (4 + 3) (g). GS = Gleason score. All comparisons consider low expression patients as the reference group. P = pairwise log-rank P-values. Statistical significance was set at P ≤ 0.05.
